Organ dysfunction as a new standard for defining sepsis
نویسندگان
چکیده
منابع مشابه
Organ dysfunction as a new standard for defining sepsis
Despite advances in intensive care and the widespread use of standardized care included in the Surviving Sepsis Campaign Guidelines, sepsis remains a leading cause of death, and the prevalence of sepsis increases concurrent with the aging process. The diagnosis of sepsis was originally based on the evidence of persistent bacteremia (septicemia) but was modified in 1992 to incorporate systemic i...
متن کاملMicrovascular dysfunction as a cause of organ dysfunction in severe sepsis
Reduced microvascular perfusion has been implicated in organ dysfunction and multiple organ failure associated with severe sepsis. The precise mechanisms underlying microvascular dysfunction remain unclear, but there are considerable experimental data showing reduced microcirculatory flow, particularly of small vessels, and increased heterogeneity. With the development of newer imaging techniqu...
متن کاملLevosimendan for the Prevention of Acute Organ Dysfunction in Sepsis.
BACKGROUND Levosimendan is a calcium-sensitizing drug with inotropic and other properties that may improve outcomes in patients with sepsis. METHODS We conducted a double-blind, randomized clinical trial to investigate whether levosimendan reduces the severity of organ dysfunction in adults with sepsis. Patients were randomly assigned to receive a blinded infusion of levosimendan (at a dose o...
متن کاملThe hematologic system as a marker of organ dysfunction in sepsis.
Sepsis with acute organ dysfunction (severe sepsis) results from a systemic proinflammatory and procoagulant response to infection. Organ dysfunction in the patient with sepsis is associated with increased mortality. Although most organs have discrete anatomical boundaries and carry out unified functions, the hematologic system is poorly circumscribed and serves several unrelated functions. Thi...
متن کاملInternational pediatric sepsis consensus conference: definitions for sepsis and organ dysfunction in pediatrics.
OBJECTIVE Although general definitions of the sepsis continuum have been published for adults, no such work has been done for the pediatric population. Physiologic and laboratory variables used to define the systemic inflammatory response syndrome (SIRS) and organ dysfunction require modification for the developmental stages of children. An international panel of 20 experts in sepsis and clinic...
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ژورنال
عنوان ژورنال: Inflammation and Regeneration
سال: 2016
ISSN: 1880-8190
DOI: 10.1186/s41232-016-0029-y